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Clinical trial to test stem cell approach for children with brain injury

Hotel Booking A unique clinical trial will gauge the safety and potential of treating children suffering traumatic brain injury with stem cells derived from their own bone marrow starting early next year at The University of Texas Medical School at Houston and Memorial Hermann Children's Hospital.

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Travel Agency The clinical trial is the first to apply stem cells to treat traumatic brain injury. It does not involve embryonic stem cells.

The theory is that these stem cells can repair the neurological damage that causes MS, the newspaper reports. "We believe that bone marrow cells have the capability to repair precisely the type of damage that we see in the brain and spinal cord in MS, " trial leader Neil Scolding, professor of clinical neurosciences for North Bristol NHS Trust, told the Telegraph.

Cheap Hotel "There is no reparative treatment for traumatic brain injury," said principal investigator Charles Cox, M.D., The Children's Fund, Inc. Distinguished Professor in Pediatric Surgery and Trauma at the medical school. "All we can do now is try to prevent secondary damage by relieving pressure on the brain caused by the initial injury."

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Flight Booking Unlike bone, muscle and other organs, the brain does not repair itself effectively. Traumatic brain injury victims can regain some function through rehabilitation. Studies show between 15 and 25 percent of children suffering severe traumatic brain injury die, and survivors of even moderate injury often are devastated for life.

All three trials used stem cells derived from bone marrow. Perhaps the best results came from the largest trial, done at the University of Frankfurt, which enlisted 204 patients, half of whom had stem cells injected three to seven days after a heart attack. Four months later, - a measure of the heart' - was significantly better in patients who got the stem cells.

Travel Agent Approved by the U.S. Food and Drug Administration and the university's Committee for the Protection of Human Subjects (CPHS), the clinical trial builds on laboratory and animal research indicating that bone-marrow derived stem cells can migrate to an injured area of the brain, differentiate into new neurons and support cells, and induce brain repair.

In conclusion, a clinical stem cell purification program using this novel device is now established in Thailand and for the first time in Southeast Asia.

Hotel Chicago "This would be an absolutely novel treatment, the first ever with potential to repair a traumatically damaged brain," said James Baumgartner, M.D., associate professor of pediatric neurosurgery and co-principal investigator on the project.

Online Booking As a Phase I clinical trial, the project's first emphasis is to establish the safety of the procedure, with a secondary goal of observing possible therapeutic effects.

Travel Health Insurance Cox and Baumgartner have permission to recruit 10 head injury patients to the study between the ages of 5 and 14 who meet criteria set for enrollment. After initial treatment and evaluation, a pediatric surgeon will approach the injured child's parents to explain the trial and request permission to enroll the child in the study.

Hotel Reservation If permission is granted, bone marrow will be extracted from the child's hip and then processed to derive two types of progenitor stem cells: mesenchymal stem cells, which differentiate into bone, cartilage and fat cells, and research indicates can also differentiate into neurons; and hematopoietic stem cells, which form all the cells needed for blood.

London Hotel Booking Preclinical research indicates that the mesenchymal stem cells play the major role in producing new neurons and support cells.

Discount Travel The Center for Cell and Gene Therapy at Baylor College of Medicine will process the bone marrow into the stem cell preparation and return it to Memorial Hermann Children's Hospital, where it will be given intravenously to the injured child.

Orlando Hotel All of this will be accomplished within 48 hours of the injury, Cox said. The children will be carefully monitored throughout for possible side effects. They will be evaluated for brain function one month and six months after the procedure to see if it is improved compared with historical data on the brain function of children of similar age who suffered a similar injury.

Booking Agency Safety trials involve too few patients to draw broad conclusions about the effectiveness of treatment. But they can set the stage for larger-scale research.

International Travel Medical "All the preclinical data suggest this is a safe procedure with substantial information suggesting a possible treatment effect," Cox said.

New York Hotel Because the children are receiving their own cells, an immunological response to the treatment is unlikely.

Online Travel Booking Even marginal improvement could mean a great deal to someone who suffers a brain injury. "It could be the difference between being able to recognize your loved ones and not being able to, or between doing things for yourself or having to rely on others. That would be a huge impact on families and on society," Cox said.

Travel Medical Insurance Trauma is far and away the main cause of death and disability among children, and the main reason children die from trauma is brain injury, Cox said.

Miami Hotel The proposal was under review for a year. The U.S. Food and Drug Administration approved Cox's Investigational New Drug (IND) application in September. The UT-Houston CPHS, the university's institutional review board for research projects, approved the project in November and will continue to monitor it.

Air Deccan Booking The project is funded by the Memorial Hermann Foundation, internal research funds from The Office of the President at The University of Texas Health Science Center at Houston, and the National Institute of Child Health and Development and the National Heart, Lung, and Blood Institute of the National Institutes of Health.

Las Vegas Nevada Travel University of Texas Health Science Center at Houston

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