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Mahidol University Annual Research Abstracts

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It depends on where the stem cells come from. If they are taken from the bone marrow, a small amount of the liquid portion of the bone marrow is removed through a needle inserted into the bone. This is done many times to collect enough stem cells for the person receiving the donated bone marrow. This is called a bone marrow aspiration. The bone marrow cells are put into a blood bag. They are often frozen for future use.

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Most stem cells are in your bone marrow. You also have some that circulate from your marrow into your blood. Bone marrow stem cells turn into red blood cells, white blood cells, or platelets to help your body stay healthy. If your bone marrow is damaged or destroyed, it can no longer make normal blood cells. In a stem cell transplant, healthy stem cells are placed in your body through an IV to help your bone marrow start to work right.

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In the early 1990s, gene therapy was used to correct a deficiency of the enzyme adenosine deaminase (ADA). Blood cells called lymphocytes were removed from the bone marrow of two children, then genes for ADA production were inserted into the cells using viruses as vectors. Finally, the cells were reinfused in the bodies of the children. Once established in the bodies, altered cells began synthesizing the enzyme ADA. Thus, the deficiency was removed and the disease resolved.

Flight Booking arate. Physiological significance of dicarboxylate transporters in the kidney is highlighted as intracellular citrate serves as the major fuel for oxidative metabolism and as the substrate in exchange for organic anion secretion. In addition, citrate reabsorption in the proximal tubule is the major determinant of final urinay citrate excretion, an important endogenous inhibitor of calcium containing kidney stone. Low urinary citrate excretion occurs in approximately half of kidney stone patients that can be ascribed in some forms of metabolic acidosis, hypokalemia or starvation. It is conceivable that defect in dicarboxylate transport could result in excessive citrate uptake and some forms of hypocitraturia. In the past few years, the genes encoded for the low- and high-affinity sodium-coupled dicarboxylate transporters were identified, and their transport properties have been extensively characterized in the heterologous expression systems. This short review deals with advance in knowledge of sodium-coupled dicarboxylate transporters in the kidney, and their potential role in stone formaltion.

Doctors use chemotherapy and radiation to destroy your bone marrow. This also gets rid of the cancer cells—along with the normal cells—in your bone marrow. Later, when you get healthy cells from a donor, those new cells will go to the marrow and be able to take over the job of making new blood cells.

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In the first study, Abecasis' team examined at gene variants associated with the CFH gene. They studied these variants in 726 people with AMD and in 268 people who didn't have the condition. - which do not - significantly contribute to the risk of AMD. They also showed that multiple variants taken together make up a high proportion of people's risk.

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Online Booking   DETECTION OF MOLECULAR VARIANTS OF BCR-ABL GENE IN BONE
  MARROW AND BLOOD OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA
  BY REVERSE -TRAN SCRIPTASE POLYMERASE CHAIN REACTION (RT-PCR)
  (NO. 251)

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Hotel Reservation Chirayu Udomsakdi-auewarakul, Yaowaluk U-pratya, Sirikwan Boonmoh, Sumit Vatanavicharn

London Hotel Booking Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Discount Travel Key words : BCR-ABL Gene Variant, Chronic Myeloid Leukemia

Orlando Hotel                     Very limited data exists in Thailand regarding the frequency of BCR-ABL leukemic gene and its prognostic implication in Thai CML patients. The objective of this study was to develop a rapid molecular assay for the detection of the two most commonly reported variants of BCR-ABL fusion gene, B2A2 and B3A2 in CML patients. Bone marrow or peripheral blood were used for RNA extraction and reverse-transcribed to cDNA for PCR amplification. 92 per cent of CML patients (91/99) were positive for BCR-ABL gene (61% B3A2 and 31% B2A2). 8/99 CML patients were BCR-ABL -negative. B3A2 and B2A2-positive patients did not have any different clinical and hematological features at presentation although B3A2 patients tended to be slightly older and had higher platelet counts. 71/71 non-CML including other MPD and leukemia cases were all negative for BCR-ABL gene. In conclusion, a rapid RT-PCR assay has now been developed for the detection of this hallmark gene in CML patients. It should be of great value in the differential diagnosis of CML from other diseases. Long-term follow-ups of CML patients with different variants are needed to determine the prognostic importance of each gene variant.

Booking Agency (UDOMSAKDI-AUEWARAKUL C, et al. J Med Assoc Thai 2000; 83: 928-935)

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Online Travel Booking   TT VIRUS INFECTION IN THAILAND ; PREVA-LENCE IN BLOOD DONORS AND
  PATIENTS WITH APLASTIC ANEMIA (NO. 252)

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Miami Hotel Chirayu Udomsakdi-Auewarakul¹, Prasert Auewarakul², Parichart Permpikul³, Surapol Issaragrisil¹

Air Deccan Booking ¹Division of Hematology, Department of Medicine, ²Division of Virology, Department of Microbiology, and ³Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Las Vegas Nevada Travel Key words : TTV infection , aplastic anemia, blood donors, viral hepatitis

Las Vegas Nv Hotel                     Aplastic anemia has been reported to occur after viral hepatitis of unknown etiology. Recently, TT virus (TTV), a novel DNA virus, was identified in a Japanese patient with posttransfusion non-A-E hepatitis. The prevalence of TTV infection was investigated among blood donors and patients with aplastic anemia in Thailand. Of 99 blood samples from blood donors, 37 tested positive for TTV DNA via semi-nested polymerase chain reaction (PCR) using TTV-specific primers. Seventeen percent of samples from blood donors younger than 20 were positive for TTV DNA, whereas 48% from donors older than 20 were positive. The high prevalence of TTV infection in Thailand is comparable to that reported in China (28%), Mongolia (43%), and Egypt (29%). Forty-two percent of newly diagnosed aplastic anemia patients tested also had TTV DNA in blood. The detection rate of TTV DNA in aplastic anemia patients does not differ significantly from rates in normal blood donors. Our present data thus argue against the role of this novel hepatitis-associated virus in the pathogenesis of aplastic anemia in Thailand. However, larger epidemiological studies may be needed to further evaluate their association.

Hotel Florence Booking Online (Int J Hematol. 2000;72:325-328. 2000 The Japanese Society of Hematology)

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Booking Delta Com   PURIFICATION OF HUMAN HEMOPOIETIC STEM CELLS FOR TRANSPLA
  NTATION IN THAILAND (NO. 253)

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London Hotel Chirayu Udomsakdi-Auewarakul¹, Yaowaluk U-pratya¹, Viroje Chongkolwatana², Voravarn S. Tanphaichitr³, Kovit Pattanapanyasat⁴, and Surapol Issaragrisil¹

Online Hotel Booking ¹Department of Medicine and Chulabhorn Bone Marrow. Transplant Center, ²Department of Transfusion Medicine, ³Department of Pediatrics, ⁴Instrument for Research Unit, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Travel Insurance                     Stem cell transplantation (SCT) has become the thearpy of choice for many hematologic and immunologic disorders. At present, only 25% of patients have suitable HLA-identical donors. In an attempt to increase the donor pool for SCT in Thailand and Southeast Asia, we developed a program whereby parents and mismatched siblings can be used as donors. In this preliminary study, after granulocyte-colony-stimulating factor (G-CSF) was given to adult donors, peripheral blood stem cells (PBSC) were collected and CD34+ cells purified using and ClinMACS immunomagnetic device (Miltenyi Biotec, Germany). In seven experiments, purified CD34+ cells could be obtained from G-CSF-stimulated PBSC in large numbers (1.71+ 0.19 x 108), with high purity (93 + 2.4%) and excellent recovery (64.28% - 85.62%). Immune reactive T and NK cells were adequately depleted to less than 0.2%. The purification procedure can be completed within 3 hours. In conclusion, a clinical stem cell purification program using this novel device is now estabilshed in Thailand and for the first time in Southeast Asia. This should allow further development of advanced SCT therapy including haploidentical and mismatched CD34+ SCT for patients lacking HLA-identical donors in this region.

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